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Arndt Siekmann, Ph.D.
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Associate Professor of Cell and Developmental Biology
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Department: Cell and Developmental Biology
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1114 Biomedical Research Building II/III
36 421 Curie Boulevard
Philadelphia, PA 19104
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36 421 Curie Boulevard
Philadelphia, PA 19104
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Office: 215-898-7805
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Education:
21 7 BS 14 (Biology) c
3d Albert-Ludwigs-Universität Freiburg, 2000.
21 8 PhD 30 (Molecular Cell Biology and Genetics) c
2d Max Planck Institute, 2004.
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Permanent link21 7 BS 14 (Biology) c
3d Albert-Ludwigs-Universität Freiburg, 2000.
21 8 PhD 30 (Molecular Cell Biology and Genetics) c
2d Max Planck Institute, 2004.
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95 Arndt F. Siekmann: Biology of vascular mural cells. Development August 2023.
10b Elvin V. Leonard, Sana S. Hasan, Arndt F. Siekmann: Temporally and regionally distinct morphogenetic processes govern zebrafish caudal fin blood vessel network expansion. Development April 2023.
169 Leonard EV, Figueroa RJ, Bussmann J, Lawson ND, Amigo JD, Siekmann AF.: Regenerating vascular mural cells in zebrafish fin blood vessels are not derived from pre-existing mural cells and differentially require Pdgfrb signalling for their development. Development 149: dev199640, Apr 2022.
147 Lange M, Ohnesorge N, Hoffmann D, Rocha SF, Benedito R, Siekmann AF.: Zebrafish mutants in vegfab can affect endothelial cell proliferation without altering ERK phosphorylation and are phenocopied by loss of PI3K signaling. Dev Biol 486: 26-43, Mar 2022.
15a Tsaryk R, Yucel N, Leonard EV, Diaz N, Bondareva O, Odenthal-Schnittler M, Arany Z, Vaquerizas JM, Schnittler H, Siekmann AF.: Shear stress switches the association of endothelial enhancers from ETV/ETS to KLF transcription factor binding sites. Sci Rep 12: 4795, Mar 2022.
116 Benman W., Berlew E.E., Deng H., Parker C., Kuznetsov I.A., Lim B., Siekmann A.F., Chow B.Y., Bugaj L.J.: Temperature-responsive optogenetic probes of cell signaling. Nature Chemical Biology December 2021.
12e Gao P, Chen C, Howell ED, Li Y, Tober J, Uzun Y, He B, Gao L, Zhu Q, Siekmann AF, Speck NA, Tan K: Transcriptional regulatory network controlling the ontogeny of hematopoietic stem cells. Genes and Development 34: 950, June 2020.
147 Santoro MM, Beltrame M, Panáková D, Siekmann AF, Tiso N, Venero Galanternik M, Jung HM, Weinstein BM: Advantages and Challenges of Cardiovascular and Lymphatic Studies in Zebrafish Research. Frontiers in Cell and Developmental Biology(7), 89, May 2019.
136 Red-Horse Kristy, Siekmann Arndt F: Veins and Arteries Build Hierarchical Branching Patterns Differently: Bottom-Up versus Top-Down. BioEssays : news and reviews in molecular, cellular and developmental biology 41(3): e1800198, Mar 2019.
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Selected Publications
f8 Zeenat Diwan, Jia Kang, Emma Tsztoo, Arndt F Siekmann : Alk1/Endoglin signaling restricts vein cell size increases in response to hemodynamic cues. Angiogenesis December 2024.95 Arndt F. Siekmann: Biology of vascular mural cells. Development August 2023.
10b Elvin V. Leonard, Sana S. Hasan, Arndt F. Siekmann: Temporally and regionally distinct morphogenetic processes govern zebrafish caudal fin blood vessel network expansion. Development April 2023.
169 Leonard EV, Figueroa RJ, Bussmann J, Lawson ND, Amigo JD, Siekmann AF.: Regenerating vascular mural cells in zebrafish fin blood vessels are not derived from pre-existing mural cells and differentially require Pdgfrb signalling for their development. Development 149: dev199640, Apr 2022.
147 Lange M, Ohnesorge N, Hoffmann D, Rocha SF, Benedito R, Siekmann AF.: Zebrafish mutants in vegfab can affect endothelial cell proliferation without altering ERK phosphorylation and are phenocopied by loss of PI3K signaling. Dev Biol 486: 26-43, Mar 2022.
15a Tsaryk R, Yucel N, Leonard EV, Diaz N, Bondareva O, Odenthal-Schnittler M, Arany Z, Vaquerizas JM, Schnittler H, Siekmann AF.: Shear stress switches the association of endothelial enhancers from ETV/ETS to KLF transcription factor binding sites. Sci Rep 12: 4795, Mar 2022.
116 Benman W., Berlew E.E., Deng H., Parker C., Kuznetsov I.A., Lim B., Siekmann A.F., Chow B.Y., Bugaj L.J.: Temperature-responsive optogenetic probes of cell signaling. Nature Chemical Biology December 2021.
12e Gao P, Chen C, Howell ED, Li Y, Tober J, Uzun Y, He B, Gao L, Zhu Q, Siekmann AF, Speck NA, Tan K: Transcriptional regulatory network controlling the ontogeny of hematopoietic stem cells. Genes and Development 34: 950, June 2020.
147 Santoro MM, Beltrame M, Panáková D, Siekmann AF, Tiso N, Venero Galanternik M, Jung HM, Weinstein BM: Advantages and Challenges of Cardiovascular and Lymphatic Studies in Zebrafish Research. Frontiers in Cell and Developmental Biology(7), 89, May 2019.
136 Red-Horse Kristy, Siekmann Arndt F: Veins and Arteries Build Hierarchical Branching Patterns Differently: Bottom-Up versus Top-Down. BioEssays : news and reviews in molecular, cellular and developmental biology 41(3): e1800198, Mar 2019.
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