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Jonathan J Edwards, MD
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Assistant Professor of Pediatrics (Cardiology)
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Department: Pediatrics
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Graduate Group Affiliations
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Contact information
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Children's Hospital of Philadelphia
39 3401 Civic Center Blvd
Philadelphia, PA 19104
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39 3401 Civic Center Blvd
Philadelphia, PA 19104
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Education:
21 7 BS 22 (Biology and Chemistry) c
32 East Carolina University , 2008.
21 7 MD c
38 Wake Forest School of Medicine , 2013.
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Permanent link21 7 BS 22 (Biology and Chemistry) c
32 East Carolina University , 2008.
21 7 MD c
38 Wake Forest School of Medicine , 2013.
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Description of Clinical Expertise
4c Pediatric Cardiomyopathy, Heart Failure, and Transplantation71
Description of Research Expertise
29 Right Ventricular Failuree 29
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1ca Wooster L, O'Connor MJ, Zhang X, Mavroudis CD, Maeda K, Ahmed H, Edwards J, Lin KY, Wittlieb-Weber C, Rossano JW, Edelson JB: Impact of Heart Transplant Allocation Changes on Waitlist Mortality and Clinical Practice in Pediatric and Adult Patients With Congenital Heart Disease and Cardiomyopathy. Circulation 151(12): 814-824, March 2025 Notes: doi: 10.1161/CIRCULATIONAHA.124.072335.
1bb Hartman H, Uy G, Uchida K, Scarborough EA, Yang Y, Barr E, Williams S, Kavar SL, Brandimarto J, Li L, Lai L, Griffin J, Yucel N, Shewale S, Rajagopal H, Eaton DM, Dorwart T, Bedi KC, Conn CS, Margulies K, Prosser B, Arany Z, Edwards JJ: ROR2 drives right ventricular heart failure via disruption of proteostasis. bioRxiv 2: doi: 10.1101/2025.02.01.635961, February 2025.
1a7 Mavroudis CD, O'Connor MJ, Wittlieb-Weber C, Edelson JB, Edwards JJ, Berger JH, Lin KY, Rossano J, Maeda K: Hybrid stage 1 palliation with simultaneous off-pump ventricular assist device placement in neonates with high-risk single ventricle anatomy: Initial experience. JTCVS Tech 24(1): 164-168, November 2024 Notes: doi: 10.1016/j.xjtc.2023.10.022.
181 Forelli N, Eaton D, Patel J, Bowman CE, Kawakami R, Kuznetsov IA, Li K, Brady C, Bedi K, Yang Y, Koya K, Megill E, Kanter DS, Smith LG, Bowman GR, Snyder N, Edwards J, Margulies K, Arany Z: SGLT2 inhibitors activate pantothenate kinase in the human heart. bioRxiv Page: doi: 10.1101/2024.07.26.605401, July 2024.
189 Holzhauser L, Reza N, Edwards JJ, Birati EY, Owens AT, McLean R, Maeda K, O’Connor MJ, Rossano JW, Mondal A, Katcoff H, Edelson JB.: Emergency Department Use and Hospital Mortality Among Heart Transplant Recipients in the United States. J Am Heart Assoc. 13(5): e032676, March 2024 Notes: doi: 10.1161/JAHA.123.032676.
138 Edwards JJ, Hartman H, Barr E, Kuznetsov I, Li K, Yang Y, Bedi Ken, Margulies KB, Arany Z: Ventricular-specific proteomic analysis of human heart failure. American Society of Clinical Investigators: Joint Meeting, Chicago, IL, Poster 2024.
18a Edwards JJ, Uy G, Hartman H, Uchida K, Scarborough EA, Yang Y, Barr E, Williams S, Brandimarto J, Li L, Yucel N, Eaton D, Conn C, Bedi K, Margulies K, Prosser B, Arany Z. : ROR2 Drives Right Ventricular Failure Via Proteostatic Imbalances. American Heart Association BCVS Scientific Sessions, Baltimore, MD, Poster 2024.
1ac Mavroudis CD, O’Connor MJ, Wittlieb-Weber C, Edelson JB, Edwards JJ, Berger JH, Lin KY, Rossano J, Maeda K. : Hybrid stage 1 palliation with simultaneous off-pump ventricular assist device placement in neonates with high-risk single ventricle anatomy: Initial experience. JTCVS Tech 24(1): 164-168, November 2023 Notes: doi: 10.1016/j.xjtc.2023.10.022.
6e Edelson JB, Zhang X, Goldstone AB, Rossano JW, O'Connor MJ, Gaynor f6 JW, Edwards JJ, Wittlieb-Weber C, Maeda K.: Reduced incidence of cardiac rejection in multi-organ transplants: A propensity matched study. Clin Transplant 37(9): e15019, September 2023 Notes: doi: 10.1111/ctr.15019.
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Selected Publications
130 Lavine K, Kadyrov F, Amrute J, Kuznetsov I, Li K, Arany Z, Edwards J, Sucharov C, Miyamoto S: Cellular and Transcriptional Landscape of Human Hypoplastic Left Heart Syndrome. Res Sq Page: doi: 10.21203/rs.3.rs-6689087/v1, May 2025.1ca Wooster L, O'Connor MJ, Zhang X, Mavroudis CD, Maeda K, Ahmed H, Edwards J, Lin KY, Wittlieb-Weber C, Rossano JW, Edelson JB: Impact of Heart Transplant Allocation Changes on Waitlist Mortality and Clinical Practice in Pediatric and Adult Patients With Congenital Heart Disease and Cardiomyopathy. Circulation 151(12): 814-824, March 2025 Notes: doi: 10.1161/CIRCULATIONAHA.124.072335.
1bb Hartman H, Uy G, Uchida K, Scarborough EA, Yang Y, Barr E, Williams S, Kavar SL, Brandimarto J, Li L, Lai L, Griffin J, Yucel N, Shewale S, Rajagopal H, Eaton DM, Dorwart T, Bedi KC, Conn CS, Margulies K, Prosser B, Arany Z, Edwards JJ: ROR2 drives right ventricular heart failure via disruption of proteostasis. bioRxiv 2: doi: 10.1101/2025.02.01.635961, February 2025.
1a7 Mavroudis CD, O'Connor MJ, Wittlieb-Weber C, Edelson JB, Edwards JJ, Berger JH, Lin KY, Rossano J, Maeda K: Hybrid stage 1 palliation with simultaneous off-pump ventricular assist device placement in neonates with high-risk single ventricle anatomy: Initial experience. JTCVS Tech 24(1): 164-168, November 2024 Notes: doi: 10.1016/j.xjtc.2023.10.022.
181 Forelli N, Eaton D, Patel J, Bowman CE, Kawakami R, Kuznetsov IA, Li K, Brady C, Bedi K, Yang Y, Koya K, Megill E, Kanter DS, Smith LG, Bowman GR, Snyder N, Edwards J, Margulies K, Arany Z: SGLT2 inhibitors activate pantothenate kinase in the human heart. bioRxiv Page: doi: 10.1101/2024.07.26.605401, July 2024.
189 Holzhauser L, Reza N, Edwards JJ, Birati EY, Owens AT, McLean R, Maeda K, O’Connor MJ, Rossano JW, Mondal A, Katcoff H, Edelson JB.: Emergency Department Use and Hospital Mortality Among Heart Transplant Recipients in the United States. J Am Heart Assoc. 13(5): e032676, March 2024 Notes: doi: 10.1161/JAHA.123.032676.
138 Edwards JJ, Hartman H, Barr E, Kuznetsov I, Li K, Yang Y, Bedi Ken, Margulies KB, Arany Z: Ventricular-specific proteomic analysis of human heart failure. American Society of Clinical Investigators: Joint Meeting, Chicago, IL, Poster 2024.
18a Edwards JJ, Uy G, Hartman H, Uchida K, Scarborough EA, Yang Y, Barr E, Williams S, Brandimarto J, Li L, Yucel N, Eaton D, Conn C, Bedi K, Margulies K, Prosser B, Arany Z. : ROR2 Drives Right Ventricular Failure Via Proteostatic Imbalances. American Heart Association BCVS Scientific Sessions, Baltimore, MD, Poster 2024.
1ac Mavroudis CD, O’Connor MJ, Wittlieb-Weber C, Edelson JB, Edwards JJ, Berger JH, Lin KY, Rossano J, Maeda K. : Hybrid stage 1 palliation with simultaneous off-pump ventricular assist device placement in neonates with high-risk single ventricle anatomy: Initial experience. JTCVS Tech 24(1): 164-168, November 2023 Notes: doi: 10.1016/j.xjtc.2023.10.022.
6e Edelson JB, Zhang X, Goldstone AB, Rossano JW, O'Connor MJ, Gaynor f6 JW, Edwards JJ, Wittlieb-Weber C, Maeda K.: Reduced incidence of cardiac rejection in multi-organ transplants: A propensity matched study. Clin Transplant 37(9): e15019, September 2023 Notes: doi: 10.1111/ctr.15019.
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