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David B. Frank, MD, PhD
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Assistant Professor of Pediatrics (Cardiology)
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Department: Pediatrics
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Contact information
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Children's Hospital of Philadelphia
23 3401 Civic Center Boulevard
4a 8NW37, Division of Pediatric Cardiology
Philadelphia, PA 19104
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23 3401 Civic Center Boulevard
4a 8NW37, Division of Pediatric Cardiology
Philadelphia, PA 19104
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Office: (267) 648-2626
32 Fax: 215-590-1340
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32 Fax: 215-590-1340
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Publications
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Education:
21 9 B.S. 19 (Biochemistry) c
37 University of Nebraska-Lincoln, 1997.
21 a Ph.D. 3a (Cell and Developmental Biology and Philosophy) c
41 Vanderbilt University School of Medicine, 2006.
21 9 M.D. c
44 Vanderbilt University of School of Medicine, 2009.
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Permanent link21 9 B.S. 19 (Biochemistry) c
37 University of Nebraska-Lincoln, 1997.
21 a Ph.D. 3a (Cell and Developmental Biology and Philosophy) c
41 Vanderbilt University School of Medicine, 2006.
21 9 M.D. c
44 Vanderbilt University of School of Medicine, 2009.
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226 Marzolini N, Brysgel TV, Rahman RJ, Essien EO, Nwe SY, Wu J, Majumder A, Patel MN, Tiwari S, Espy CL, Dong F, Santos-De León SA, Shah A, Shuvaev VV, Hood ED, Chase LS, Weissman D, Katzen JB, Frank DB, Bennett ML, Marcos-Contreras OA, Myerson JW, Muzykantov VR, Reyes-Esteves S, Brenner JS. : Targeting DNA-LNPs to Endothelial Cells Improves Expression Magnitude, Duration, and Specificity. Advanced Science Page: 10.1002/advs.202515480, Jan 2026 Notes: Online ahead of print.
126 Snitow ME, Michki SN, Chaudhry FN, Park Y, Dherwani R, Katzen JB, Frank DB, Zepp JA: Stc1-expressing myofibroblasts are a developmentally distinct lineage cleared through apoptosis in the neonatal lung. Cell Rep Dec 2025.
13c Meluskey H, Blowey B, O'Brien AB, O'Byrne ML, Rome JJ, Frank DB, Avitabile CM, Gupta M, Tang J, Butler KL, Mavroudis CD, Fuller S, Callahan R. : Systemic Sirolimus Monitoring in Pediatric Pulmonary Vein Stenosis. Pediatr Cardiol. October 2025.
250 Niccum M, Avitabile CM, Albizem D, Meluskey H, Penney C, Hanna BD, O'Byrne ML, Bshouty Z, Frank DB. Pulmonary Vascular Compromise Is Associated With Survival in Pediatric Pulmonary Hypertension: A New Computational Model. Pulm Circ. 2025 Sep 1;15(3):e70156. doi: 10.1002/pul2.70156. PMID: 40904895; PMCID: PMC12401941.: Pulmonary Vascular Compromise Is Associated With Survival in Pediatric Pulmonary Hypertension: A New Computational Model. Pulm Circ. 15(3), September 2025 Notes: Editorial accompaniment in Pulmonary Circulation 4b https://onlinelibrary.wiley.com/doi/10.1002/pul2.70218.
233 Chen C, Xu J, Sussman JH, Vincent T, Tumulty JS, Yoshimura S, Alikarami F, Yu W, Ding YY, Chen CH, Li EY, Yang A, Qin X, Bandyopadhyay S, Peng J, Pölönen P, Newman H, Wood BL, Hu J, Shraim R, Hughes AD, Diorio C, Uppuluri L, Shi G, Ryan T, Fuller T, Loh ML, Raetz EA, Hunger SP, Pounds SB, Mullighan CG, Frank D, Yang JJ, Bernt KM, Teachey DT, Tan K. : Single-cell panleukemia signatures of HSPC-like blasts predict drug response and clinical outcome. Blood 145(23): 2685-2700, Jun 2025.
116 Vega TF, Huber M, Jensen EA, Avitabile CM, Lorch SA, Gibbs KA, O'Byrne ML, Frank DB, Bamat NA: Pulmonary vasodilator use in very preterm infants in United States children's hospitals. J Perinatol May 2025.
1ad Shirazi SP, Negretti NM, Jetter CS, Sharkey AL, Garg S, Kapp ME, Wilkins D, Fortier G, Mallapragada S, Banovich NE, Eldredge LC, Deutsch GH, Wright CVE, Frank DB, Kropski JA, Sucre JMS: Bronchopulmonary dysplasia with pulmonary hypertension associates with semaphorin signaling loss and functionally decreased FOXF1 expression. Nat Commun 30(16), May 2025.
142 Wen J., Chandrasekaran P., Jin A., Pankin J., Lu M., Liberti D.C., Zepp J.A., Jain R., Morrisey E.E., Michki S.N., Frank D.B. : A spatiotemporal cell atlas of cardiopulmonary progenitor cell allocation during development. Cell Rep 44(4), April 2025.
22f Maureen Peers de Nieuwburgh, Mallory Hunt, Prashant Chandrasekaran, Tiffaney L Vincent, Kevin B Hayes, Isabel R Randazz, Meredith Gunder , Felix R De Bie, Arthur Colson, Minqi Lu, Hongbo Wen, Sylvia N Michki, Jack Rychik , Fréderic Debiève, Jeremy Katzen, Lisa R Young, Marcus G Davey, Alan W Flake, J William Gaynor, David B Frank: Chronic Hypoxia in an EXTrauterine Environment for Neonatal Development Impairs Lung Development. Am J Respir Cell Mol Biol 72(4): 441-452, April 2025.
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Selected Publications
192 Wen H, Liberti DC, Chandrasekaran P, Parveen S, Quansah KK, Kim M, Lange AN, Marquis AT, Michki SN, Jin A, Lu M, Fasan AA, Suresh S, Shirazi SP, Young LR, Sucre JM, Basil MC, Jain R, Frank DB.: BRD4 promotes endodermal cell fate during mammalian lung development. JCI Insight Page: doi: 10.1172/jci.insight.194683, February 2026.226 Marzolini N, Brysgel TV, Rahman RJ, Essien EO, Nwe SY, Wu J, Majumder A, Patel MN, Tiwari S, Espy CL, Dong F, Santos-De León SA, Shah A, Shuvaev VV, Hood ED, Chase LS, Weissman D, Katzen JB, Frank DB, Bennett ML, Marcos-Contreras OA, Myerson JW, Muzykantov VR, Reyes-Esteves S, Brenner JS. : Targeting DNA-LNPs to Endothelial Cells Improves Expression Magnitude, Duration, and Specificity. Advanced Science Page: 10.1002/advs.202515480, Jan 2026 Notes: Online ahead of print.
126 Snitow ME, Michki SN, Chaudhry FN, Park Y, Dherwani R, Katzen JB, Frank DB, Zepp JA: Stc1-expressing myofibroblasts are a developmentally distinct lineage cleared through apoptosis in the neonatal lung. Cell Rep Dec 2025.
13c Meluskey H, Blowey B, O'Brien AB, O'Byrne ML, Rome JJ, Frank DB, Avitabile CM, Gupta M, Tang J, Butler KL, Mavroudis CD, Fuller S, Callahan R. : Systemic Sirolimus Monitoring in Pediatric Pulmonary Vein Stenosis. Pediatr Cardiol. October 2025.
250 Niccum M, Avitabile CM, Albizem D, Meluskey H, Penney C, Hanna BD, O'Byrne ML, Bshouty Z, Frank DB. Pulmonary Vascular Compromise Is Associated With Survival in Pediatric Pulmonary Hypertension: A New Computational Model. Pulm Circ. 2025 Sep 1;15(3):e70156. doi: 10.1002/pul2.70156. PMID: 40904895; PMCID: PMC12401941.: Pulmonary Vascular Compromise Is Associated With Survival in Pediatric Pulmonary Hypertension: A New Computational Model. Pulm Circ. 15(3), September 2025 Notes: Editorial accompaniment in Pulmonary Circulation 4b https://onlinelibrary.wiley.com/doi/10.1002/pul2.70218.
233 Chen C, Xu J, Sussman JH, Vincent T, Tumulty JS, Yoshimura S, Alikarami F, Yu W, Ding YY, Chen CH, Li EY, Yang A, Qin X, Bandyopadhyay S, Peng J, Pölönen P, Newman H, Wood BL, Hu J, Shraim R, Hughes AD, Diorio C, Uppuluri L, Shi G, Ryan T, Fuller T, Loh ML, Raetz EA, Hunger SP, Pounds SB, Mullighan CG, Frank D, Yang JJ, Bernt KM, Teachey DT, Tan K. : Single-cell panleukemia signatures of HSPC-like blasts predict drug response and clinical outcome. Blood 145(23): 2685-2700, Jun 2025.
116 Vega TF, Huber M, Jensen EA, Avitabile CM, Lorch SA, Gibbs KA, O'Byrne ML, Frank DB, Bamat NA: Pulmonary vasodilator use in very preterm infants in United States children's hospitals. J Perinatol May 2025.
1ad Shirazi SP, Negretti NM, Jetter CS, Sharkey AL, Garg S, Kapp ME, Wilkins D, Fortier G, Mallapragada S, Banovich NE, Eldredge LC, Deutsch GH, Wright CVE, Frank DB, Kropski JA, Sucre JMS: Bronchopulmonary dysplasia with pulmonary hypertension associates with semaphorin signaling loss and functionally decreased FOXF1 expression. Nat Commun 30(16), May 2025.
142 Wen J., Chandrasekaran P., Jin A., Pankin J., Lu M., Liberti D.C., Zepp J.A., Jain R., Morrisey E.E., Michki S.N., Frank D.B. : A spatiotemporal cell atlas of cardiopulmonary progenitor cell allocation during development. Cell Rep 44(4), April 2025.
22f Maureen Peers de Nieuwburgh, Mallory Hunt, Prashant Chandrasekaran, Tiffaney L Vincent, Kevin B Hayes, Isabel R Randazz, Meredith Gunder , Felix R De Bie, Arthur Colson, Minqi Lu, Hongbo Wen, Sylvia N Michki, Jack Rychik , Fréderic Debiève, Jeremy Katzen, Lisa R Young, Marcus G Davey, Alan W Flake, J William Gaynor, David B Frank: Chronic Hypoxia in an EXTrauterine Environment for Neonatal Development Impairs Lung Development. Am J Respir Cell Mol Biol 72(4): 441-452, April 2025.
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