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  • Faculty
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  • Jonathan A. Raper
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Faculty

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Jonathan A. Raper, Ph.D.

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Emeritus Professor of Neuroscience
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Department: Neuroscience
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1f Graduate Group Affiliations 8 a
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46 Contact information
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105 Johnson Pavilion
42 Department of Neuroscience
Philadelphia, PA 19104-6021
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2e Office: 215-898-2180
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Email: raperj@pennmedicine.upenn.edu
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18 Publications
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13 Education:
21 9 B.A. 17 (Psychology) c
29 Harvard College , 1974.
 21 a Ph.D. 3a (Cellular Neurophysiology with Daniel Hartline) c
3e University of California at San Diego, 1979.
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Links
97 Search PubMed for articles
 44 Cell and Molecular Biology graduate group faculty webpage.
3e Neuroscience graduate group faculty webpage.
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b6 > Perelman School of Medicine   > Faculty   > Details a
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Description of Research Expertise

2b Research Interests
3d developmental neurobiology, especially axon guidance
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bb Key words: axon guidance, developmental neurobiology, Molecular biology; tissue culture; Protein biochemistry; Videomicroscopy, expression cloning; mouse, chick, zebrafish.
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26 Description of Research
21e My laboratory is focused on defining and characterizing the cues that guide growing axons to their targets in the developing nervous system. We are working with embryonic zebrafish to study the development of the primary olfactory projection. We have developed transgenic lines of fish in which specific subsets of olfactory neurons project to well defined, identifiable target locations in the olfactory bulb. We are using these transgenic lines crossed into mutant lines to study the role of candidate guidance cues in axon guidance.
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Selected Publications

133 Lakhina V, Marcaccio CL, Shao X, Lush ME, Jain RA, Fujimoto E, Bonkowsky JL, Granato M, Raper JA.: Netrin/DCC signaling guides olfactory sensory axons to their correct location in the olfactory bulb. J Neurosci. 32(13): 4440-56, 2012.

 f6 Twery EN, Raper JA.: SDF1-induced antagonism of axonal repulsion requires multiple G-protein coupled signaling components that work in parallel. PLoS One 6(4): e18896, 2011.

 159 Xu, H., S.G. Leinwand, A.L. Dell, E. Fried-Cassorla, and J.A. Raper: The calmodulin-stimulated adenylate cyclase ADCY8 sets the sensssssitivity of zebrafish retinal axons to midline repellents and it required for normal midline crossing. J. Neurosci. 30: 7423-7433, 2010.

 d8 Raper, JA and C. Mason: Cellular Strategies of Axonal Pathfinding. Cold Spring Harb. Perspect. Biol. Cold Spring Harbor Press, 2:a001933, 2010.

 d2 Kapfhammer JP, Xu H, Raper JA.: The detection and quantification of growth cone collapsing activities. Nat Protoc. 2(8): 2005-2011, 2008.

 110 Chalasani, S.H., A. Sabol, H. Xu, M.A. Gyda, K. Rasband, M. Granato, C-B. Chien, and J.A. Raper: Stromal Cell-Derived Factor-1 antagonizes Slit/Robo signaling in vivo. J. Neurosci. 27: 293-80, 2007.

 fc Jia,L., L. Cheng, and J.A.Raper : Slit/Robo signaling is necessary to confine early neural crest cells to the ventral migratory pathway in the trunk. Dev. Biol 282: 411-421, 2005.

 126 Chalasani S.H., F. Baribaud, C.M. Coughlan, M.J. Sunshine, V.M.Y. Lee, R.W. Doms, D.R. Littman and J.A. Raper: The chemokine SDF-1 promotes the survival of embryonic retinal ganglion cells. J. Neurosci. 23: 4601-12, 2003.

 12e Chalasani, S.H., K.A. Sabelko, M.J. Sunshine, D.R. Littman, and J.A. Raper : A chemokine, SDF-1, reduces the effectiveness of multiple axonal repellents and is required for normal axon pathfinding. J Neurosci. Page: 1360-7, 2003.

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