Faculty

Iain Mathieson, Ph.D.

Associate Professor of Genetics

Department: Genetics

Graduate Group Affiliations

Contact information

405A Clinical Research Building
415 Curie Boulevard
Philadelphia, PA 19104-6145

Office: 215-573-1835

Email:
mathi@upenn.edu

Education:
BA (Mathematics)
Cambridge University, 2005.
MPhil (Statistical Science)
Cambridge University, 2006.
DPhil (Genomic Medicine & Statistics)
Oxford University, 2013.

Links
Lab website

Permanent link

> Perelman School of Medicine > Faculty > Details

Selected Publications

Aw AJ, Mandla R, Shi Z; Penn Medicine Biobank; Pasaniuc B, Mathieson I.: Hidden structure in polygenic scores and the challenge of disentangling ancestry interactions in admixed populations. Genetics (In press) Oct 2025.

Mathieson I.: Polygenic prediction of human complex traits using ancient DNA. Curr Opin Genet Dev 95: 102396, Aug 2025.

Mies G, Tsao NL, Houy A, Coupland SE, Kalirai H, Försti A, Hemminki K, Thomsen H, Stern MH, Shields CL, Damrauer SM, Ewens KG, Ganguly A, Mathieson I.: Meta-analysis of uveal melanoma genome-wide association studies identifies novel risk loci and population effect size heterogeneity. HGG Adv 6: 100465, Jul 2025.

Cox SL, Kaymak-Loveless K, Shin C, Alihodžić T, Alt KW, Atanassova N, Binder D, Čaušević-Bully M, Chohadzhiev A, Chohadzhiev S, Duday H, Gaydarska B, Khudaverdyan A, Micó Perez R, Nicklisch N, Novak M, Oliart Caravatti C, Réveillas H, Rivollat M, Rottier S, Tončinić D, Zäuner S, Mathieson I: Effects of ancestry, agriculture, and lactase persistence on the stature of prehistoric Europeans. bioRxiv (In revision Current Biology) Page: https://doi.org/10.1101/2025.07.11.664181, Jul 2025.

Ramos-Almodóvar F, Gao Z, Voight BF, Mathieson I.: Methylation-associated mutagenesis underlies variation in the mutation spectrum across eukaryotes. bioRxiv (In review PNAS) Page: doi: 10.1101/2025.05.28.656604, May 2025.

Barton AR, Santander CG, Skoglund P, Moltke I, Reich D, Mathieson I.: Insufficient evidence for natural selection associated with the Black Death. Nature Page: :E19-E22, Feb 2025.

Cox SL, Nicklisch N, Francken M, Wahl J, Meller H, Haak W, Alt KW, Rosenstock E, Mathieson I.: Socio-cultural practices may have affected sex differences in stature in Early Neolithic Europe. Nat Hum Behav Dec 2024.

Riley R, Mathieson I, Mathieson S.: Interpreting generative adversarial networks to infer natural selection from genetic data. Genetics 226: iyae024, Apr 2024.

Poyraz L, Colbran LL, Mathieson I.: Predicting Functional Consequences of Recent Natural Selection in Britain. Mol Biol Evol 41: msae053, Mar 2024.

Schurr TG, Shengelia R, Shamoon-Pour M, Chitanava D, Laliashvili S, Laliashvili I, Kibret R, Kume-Kangkolo Y, Akhvlediani I, Bitadze L, Mathieson I, Yardumian A.: Genetic Analysis of Mingrelians Reveals Long-Term Continuity of Populations in Western Georgia (Caucasus). Genome Biol Evol 15: evad198, Nov 2023.