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RESEARCH

THE HUMAN MICROBIOME

HIV PATHOGENESIS

DNA INTEGRATION IN
HUMAN GENE THERAPY

ABOUT US

Our goal is to carry out research on interactions between humans and their microbes that has the maximum positive effect on human welfare.  Often this involves development and implementation of new technology for basic research and biotechnology.  One research focus involves studies of the human microbiome, the gigantic community of microbes that live associated with every human.  The human microbiome has been reported to influence health and most human diseases, offering numerous opportunities for engineering to improve human health.  Another area of research centers on HIV, including development of new methods and implementing novel high-throughput methods for understanding replication and devising therapeutics.  A third related area involves methods development for understanding and improving methods for human gene therapy.

SELECTED PUBLICATIONS

HIV Replication in LEGO Mosaic.
AIDS Res Hum Retroviruses.
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AIDS Res Hum Retroviruses 2015
Multi-center Comparison of Lung and Oral Microbiomes of HIV-infected and HIV-uninfected Individuals.
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Am J Respir Crit Care Med 2015
Power and sample-size estimation for microbiome studies using pairwise distances and PERMANOVA.
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Bioinformatics 2015
BIRC2/cIAP1 Is a Negative Regulator of HIV-1 Transcription and Can Be Targeted by Smac Mimetics to Promote Reversal of Viral Latency.
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Cell Host Microbe 2015
Alterations of the Subgingival Microbiota in Pediatric Crohn’s Disease Studied Longitudinally in Discovery and Validation Cohorts.
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